Performance of HDTMA-Br-Modified Indonesian Zeolite as a Drug Carrier Candidate for Diclofenac Sodium

Diclofenac sodium is a non-steroidal anti-inflammatory drug with relatively short release time. This time promotes more frequent consumption and could lead to side effects in the stomach, e.g., gastrointestinal disorders, bleeding, gastric ulcers. A delivery system slow-release activity one of promising technologies control amount released stomach. surfactant-modified natural zeolite as carrier for diclofenac has been used this study. study focused on preparation, characterization, performance HDTMA-modified sodium. The underwent chemical physical activation, well milling prior use. It was proven that dominated by mordenite clinoptilolite high stability properties towards acid treatments, indicated XRD patterns. modification surface using HDTMABr also successfully performed, appearance peaks at wavenumbers 2923.05 cm-1 2853.39 (symmetrical asymmetrical CH2 strains HDTMA molecules, respectively) FTIR spectra. synthesized showed an excellent property such area, pore-volume, size, BET-BJH isotherms nitrogen adsorption. zeolite-based studied investigating adsorption-desorption behavior adsorbed 54.01% pH 7.5, contact 60 min, initial concentration 100 ppm. 73.95% be from adsorbent 8 h, mimicking length metabolism human body.